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High Prevalence of Atrial Fibrillation Among Patients With Ischemic Stroke.
Atrial fibrillation (AF) is a common cause of devastating but potentially preventable stroke. Estimates of the prevalence of AF among patients with stroke vary considerably because of difficulties in detection of intermittent, silent AF. Better recognition of AF in this patient group may help to identify and offer protection to individuals at risk. Our aim was to determine the nationwide prevalenc
A review of heat transfer and pressure drop characteristics of single and two-phase microchannels
An impressive amount of investigations has been devoted to enhancing thermal performance of microchannels. The small size of microchannels and their ability to dissipate heat makes them as one of the best choices for the electronic cooling systems. In this paper, a comprehensive review of available studies regarding single and two-phase microchannels is presented and analyzed. 219 articles are rev
On the influence of bimodal size distributions in particle sizing using laser-induced incandescence
Time-resolved laser-induced incandescence (LII) is a technique for in-situ soot particle size distribution measurements with the limitation that the distribution function has to be assumed (often monodisperse or lognormal) in the signal analysis. Since it is established that size distributions sometimes are bimodal, it is of interest to understand the influence from such distributions on the LII s
Rho-kinase regulates induction of T-cell immune dysfunction in abdominal sepsis.
T-cell dysfunction increases susceptibility to infections in patients with sepsis. In the present study, we hypothesized that Rho-kinase signaling might regulate induction of T-cell dysfunction in abdominal sepsis. Male C57BL/6 mice were treated with the specific Rho-kinase inhibitor Y-27632 (5 mg/kg) prior to cecal ligation and puncture (CLP). Spleen CD4 T-cell apoptosis, proliferation and regula
Relatives' experiences of the Boston Psychiatric Rehabilitation approach: A qualitative study.
The Boston Psychiatric Rehabilitation (BPR) approach is individualized and characterized by being based entirely on the individual's unique needs and preferences in the areas of working, learning, social contacts, and living environment. Relatives of clients in mental health services influence the client's possibilities for recovery by their everyday relationship. Relatives have, however, traditio
Are ectomycorrhizal fungi alleviating or aggravating nitrogen limitation of tree growth in boreal forests?
Symbioses between plant roots and mycorrhizal fungi are thought to enhance plant uptake of nutrients through a favourable exchange for photosynthates. Ectomycorrhizal fungi are considered to play this vital role for trees in nitrogen (N)-limited boreal forests. We followed symbiotic carbon (C)N exchange in a large-scale boreal pine forest experiment by tracing 13CO2 absorbed through tree photosynt
Rules for priming and inhibition of glycosaminoglycan biosynthesis; probing the beta 4GalT7 active site
beta-1,4-Gatactosyltransferase 7 (beta 4GalT7) is an essential enzyme in the biosynthesis of glycosaminoglycan (GAG) chains of proteoglycans (PGs). Mammalian cells produce PGs, which are involved in biological processes such as cell growth and differentiation. The PGs consist of a core protein, with one or several GAG chains attached. Both the structure of the PGs and the GAG chains, and the expre
Short-term effects of thinning, clear-cutting and stump harvesting on methane exchange in a boreal forest
Forest management practices can alter soil conditions, affecting the consumption and production processes that control soil methane (CH4) exchange. We studied the short-term effects of thinning, clear-cutting and stump harvesting on the CH4 exchange between soil and atmosphere at a boreal forest site in central Sweden, using an undisturbed plot as the control. Chambers in combination with a highpr
Heparin-binding protein: An early indicator of critical illness and predictor of outcome in cardiac arrest.
AIM: To investigate plasma levels of the neutrophil-borne heparin-binding protein (HBP) in patients with induced hypothermia after cardiac arrest (CA), and to study any association to severity of organ failure, incidence of infection and neurological outcome. METHODS: This study included 84 patients with CA of mixed origin who were treated with hypothermia. Plasma samples from 7 time points during
Applying dried blood spot sampling with LCMS quantification in the clinical development phase of tasquinimod.
Tasquinimod is an orally active anticancer drug in late clinical development. Here we describe the development and validation of a bioanalytical method based upon dried blood spot analysis in combination with LCMS/MS and stable isotope dilution.
Identification of SPARC-like 1 Protein as Part of a Biomarker Panel for Alzheimer's Disease in Cerebrospinal Fluid
We have used proteomic fingerprinting to investigate diagnosis of Alzheimer's disease (AD). Samples of lumbar cerebrospinal fluid (CSF) from clinically-diagnosed AD cases (n = 33), age-matched controls (n = 20), and mild cognitive impairment (MCI) patients (n = 10) were used to obtain proteomic profiles, followed by bioinformatic analysis that generated a set of potential biomarkers in CSF samples
Evolutionary history of the Dactylorhiza maculata polyploid complex (Orchidaceae)
Taxonomic complexity may be associated with migration history and polyploidy. We used plastid and nuclear DNA markers to investigate the evolutionary history of the systematically challenging Dactylorhiza maculata polyploid complex. A total of 1833 individuals from 298 populations from throughout Europe were analysed. We found that gene flow was limited between the two major taxa, diploid ssp. fuc
Exploring single-photon ionization on the attosecond time scale
One of the fundamental processes in nature is the photoelectric effect in which an electron is ripped away from its atom via the interaction with a photon. This process was long believed to be instantaneous but with the development of attosecond pulses (1 as 10(-18) s) we can finally get an insight into its dynamic. Here we measure a delay in ionization time between two differently bound electrons
Overload effects on fatigue crack-tip fields under plane stress conditions: surface and bulk analysis
The surface crack opening displacements are characterised by digital image correlation for a (thin) plane stress 316 stainless steel compact tension sample subjected to an overload event. This supports a traditional plasticity-induced closure interpretation showing a knee in the closure response prior to overload, an absence of closure in the accelerated growth regime followed by accentuated closu
Validation of a Self-Concept Scale for Lynch Syndrome in Different Nationalities
Learning about hereditary cancer may influence an individual's self-concept, which otherwise represents a complex but stable cognitive structure. Recently, a 20-statement self-concept scale, with subscales related to stigma-vulnerability and bowel symptom-related anxiety, was developed for Lynch syndrome. We compared the performance of this scale in 591 mutation carriers from Denmark, Sweden and C
Evaluated Activation Cross Section Data for Proton Induced Nuclear Reactions on W up to 3 GeV Incident Energy
Evaluated cross-section data files were prepared for stable tungsten isotopes with the objective to provide reliable and sound nuclear data for activation and inventory calculations of the European Spallation Source, which utilizes a tungsten target. The data files contain yields of radionuclides produced by proton induced reactions with incident energies up to 3 GeV. The calculations of cross-sec
The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry.
Particle image velocimetry has been the preferred experimental technique with which to study the aerodynamics of animal flight for over a decade. In that time, hardware has become more accessible and the software has progressed from the acquisition of planes through the flow field to the reconstruction of small volumetric measurements. Until now, it has not been possible to capture large volumes t
Measurement of charged-particle spectra in Pb plus Pb collisions at root s(NN)=2.76 TeV with the ATLAS detector at the LHC
Charged-particle spectra obtained in Pb+Pb interactions at root s(NN) = 2.76TeV and pp interactions at root s(NN) = 2.76TeV with the ATLAS detector at the LHC are presented, using data with integrated luminosities of 0.15 nb(-1) and 4.2 pb(-1), respectively, in a wide transverse momentum (0.5 < p(T) < 150 GeV) and pseudorapidity (vertical bar eta vertical bar < 2) range. For Pb+Pb collisions, the
Work outcomes and their predictors in the Redesigning Daily Occupations (ReDO) rehabilitation programme for women with stress-related disorders.
Previous research has shown that the Redesigning Daily Occupations programme reduced the degree of sick leave and increased return to work rates among women on sick leave for stress-related disorders when compared with "care as usual". To further investigate the Redesigning Daily Occupations intervention, this study explored changes in the work situation from baseline to a 12-month follow-up in th
