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Optical microscope based on multispectral imaging applied to Plasmodium diagnosis

We have adapted an optical transmission microscope to multispectral imaging in order to diagnose Plasmodium falciparum without using fluorescent labels for parasites as is the case for the thick and thin blood smears. We show how a set of monochromatic Light Emitting Diodes (LEDs) has provided an efficient contrast and spatial resolution to identify the parasites inside the erythrocytes. The obtai

Pybkgmodel - a background modelling toolbox for the CTA

Despite the advancement in background rejection techniques, observation of the very-high-energy gamma-ray sky by imaging atmospheric Cherenkov telescopes (IACTs) are subject to an irreducible background from gamma-like hadron- or electron-induced air showers. The determination of this residual background is crucial for accurate spectral and spatial measurements. The Cherenkov Telescope Array (CTA)

Depth of Anaesthesia Measured by Patient State Index (PSi) Does Not Correlate With Increased Seizure Duration During Electroconvulsive Therapy

BACKGROUND: Seizure duration during electroconvulsive therapy (ECT) correlates with treatment efficacy and may be influenced by depth of anaesthesia. The Patient State Index (PSi), derived from processed EEG, offers a potential method to monitor depth of anaesthesia during ECT. This study examined the correlation between pre-ictal PSi and EEG-seizure duration.METHODS: In this prospective observati

The Virtual Reality Tour : Immersive Preoperative Information for Elderly Patients

Background/Objectives: Older patients are more susceptible to the process of understanding and retrieving information. To provide adequate preoperative information, reduce their vulnerability and anxiety, and thereby facilitate pre-, intra-, and postoperative care, the adoption of new information technologies is essential. This study aimed to explore elderly patients' experiences and perceptions o

Cross‑system transfer of fatty acids from aquatic insects supports terrestrial insectivore condition and reproductive success

Cross-system fluxes of aquatic insects rich in omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may subsidise insectivorous vertebrates that are suffering due to terrestrial insect declines. The benefits of high ω-3 LC-PUFA diets, such as improved growth and immunocompetence, have previously been demonstrated fo

edge: the emergence of dwarf galaxy scaling relations from cosmological radiation-hydrodynamics simulations

We present a new suite of edge ('Engineering Dwarfs at Galaxy formation's Edge') cosmological zoom simulations. The suite includes 15 radiation-hydrodynamical dwarf galaxies covering the ultrafaint to the dwarf irregular regime () to enable comparisons with observed scaling relations. Each object in the suite is evolved at high resolution () and includes stellar radiation, winds, and supernova fee

Radon-222 monitoring at German ICOS atmosphere stations

Atmospheric measurements of the short-lived radioactive noble gas radon-222 (222Rn) have many applications. Its concentrations are driven by atmospheric mixing as well as seasonal variations, which follow the seasonality of 222Rn exhalation from continental soils, with lower values during the wet winter and spring months compared to more dry summer conditions. Hence, it can be used as a tracer to

Grid-connected inverter for photovoltaic energy harvesting: Advances in topologies and control techniques

This paper reviews the recent advancements in inverter topologies and control techniques for grid-connected photovoltaic systems. As photovoltaic penetration continues to increase, modern power systems need high performance inverters which can maintain reliability, power quality and compliance with evolving grid codes. Although these inverters are advancing over the years, there is no existing rev

Measurement report : Eight years of greenhouse gas fluxes at Saclay, France, estimated with the Radon Tracer Method

Here, we use carbon dioxide (CO2), methane (CH4), carbon monoxide (CO), nitrous oxide (N2O) and radon (222Rn) data from the Saclay ICOS tall tower in France to estimate CO2, CH4 and CO fluxes within the station footprint from January 2017 to October 2024 and N2O fluxes from February 2019 to October 2024 using the Radon Tracer Method (RTM). We first performed a sensitivity study of this method appl

Partial wrist denervation versus patient education and self‑managed exercise therapy in patients with wrist osteoarthritis: study protocol for a randomized controlled trial

Background: Wrist osteoarthritis (OA) is mainly posttraumatic, affects younger individuals than other types of OA, and can lead to significant disability. The first-line treatment is patient education and exercise, but surgery may be considered if symptoms persist. A mini-invasive surgical approach for wrist OA is partial wrist denervation, which,in theory, alleviates pain by resecting sensory ner

REACtiVe-2 : phase I evaluation of dendritic cell vaccination and agonistic CD40 therapy following (m)FOLFIRINOX in metastatic pancreatic cancer

In pancreatic ductal adenocarcinoma (PDAC), the dense desmoplastic stroma and insufficient infiltrating T cells represent a significant barrier to effective immunotherapy. In this phase I, dose-escalation study, previously registered at the Dutch Trial Register and later on at ClinicalTrial (NCT05650918), we administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-spe

Ancient petrified time capsules of knowledge – the fossil collections of Lund University, Sweden

Natural history collections hold immense global significance – not only as historical archives but also as precious resources for novel scientific discoveries. These collections, housed in museums and institutions worldwide, are (or should be) accessible and open for study. In this paper, we provide a brief history of the fossil collections at Lund University, Sweden, tracing their origins, key hi

Monitoring CO2 in diverse European cities: highlighting needs and challenges through characterisation

For the development of a joint European capacity for monitoring CO2 emissions, we created the framework “CO2 Monitoring Challenges City Mapbooks v1.0” (CMC-CITYMAP). It includes a Jupyter notebook tool (Storm et al., 2025a, https://doi.org/10.18160/P8SV-B99F) which we use to characterise and cluster cities based on aspects relevant for different CO2 monitoring challenges. These include:a. determin

Searching for long-lived particles in free neutron experiments

We explore the decay of free neutrons into exotic long-lived particles, whose decays could be detected in the next-generation free neutron experiments. We show that such a possibility is viable as long as the exotic particle is highly mass-degenerate with the neutron, avoiding exclusion by large-volume detectors. We estimate the number of observable events and identify the most promising final sta

Smart glasses for monitoring vital signs in anaesthesia care settings : a qualitative simulation study

BACKGROUND: Monitoring of vital signs is essential in anaesthesia care and plays a key role in preventing adverse events. Technological innovation is recognised as an important factor in enhancing patient safety. Smart glasses represent a novel tool that may support anaesthesia professionals in monitoring vital signs; however, their practical use and user experiences in anaesthesia care remain ins

Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240

This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. Methods: DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2

Opioid-Free Anesthesia in Perioperative Care : Findings From a Swedish Web-Based Survey

OBJECTIVES: Opioid-free anesthesia (OFA) is a promising alternative to traditional opioid-based anesthesia. Research indicates that OFA reduces postoperative opioid consumption and related adverse effects while maintaining effective pain control and patient safety. Despite these benefits, clinical adoption of OFA remains limited, possible due to gaps in evidence. To bridge this knowledge gap, a we

Improving the modeling of tree establishment in LPJ-GUESS by introducing conspecific clustering

This thesis explores the spatial distribution of trees in the LPJ-GUESS dynamic global vegetation model and proposes some modification to improve ecological realism. In the standard version of LPJ-GUESS, the model simplifies forest dynamics by averaging individuals into cohorts and disregarding competition, canopy interactions or resource allocation completely. To improve this, a newer version was

Measurement of K̄ N scattering below the K̄ N mass threshold

We measured πΣ invariant mass spectra below and above the K̄N mass threshold in the K-d → NπΣ reaction in order to study the K̄N interaction and the Λ(1405) resonance. This reaction can be described by the two-step process: (i) K-N1 → K̄N followed by (ii) K̄N2 → πΣ, where N1 and N2 are nucleons bound in the deuteron. We deduced the S -wave scattering amplitude of K̄N → K̄N as well as K̄N → πΣ in I

Association between sedentary behavior and sleep quality among urban white-collar workers with or at risk of metabolic syndrome : a secondary analysis of a randomized 3-month workplace lifestyle intervention trial

Objectives: Many Japanese adults experience poor sleep quality. Prolonged sedentary behavior negatively affects health, including sleep-associated problems. We investigated the association between sedentary behavior and sleep quality among urban white-collar workers in Japan with metabolic syndrome or at risk of metabolic syndrome, a population thought to have particularly prolonged sedentary time